Sixteen out of every 100 Youth19 participants (16%) reported they were same- or multiple-sex attracted, not sure, or not attracted to any sex. Most of these students reported positive home and family environments. However, a greater proportion of same- or multiple-sex attracted students reported social and school isolation and unsafe environments than their exclusively different-sex attracted peers. There are important actions that families, schools, communities and government can take to support the health and wellbeing of same- and multiple-sex attracted students.